IVÉ Wellness: Science-Backed IV Drip Ingredients

Your Pathway to Wellness Begins Here

At IVÉ Wellness, our IV drip therapies are carefully formulated with clinically proven ingredients to support hydration, vitality, recovery, and immune health. Each infusion is delivered by our experienced medical team—right to your door, at your home, hotel, or office. Explore our core ingredients below and discover the science behind each vitamin, antioxidant, and micronutrient we use to help you look, feel, and perform your best.

IV Fluid Base: Normal Saline & Lactated Ringer's

What Is It?

Normal Saline (0.9% Sodium Chloride) is an isotonic solution containing 9g of NaCl per liter of sterile water.
Lactated Ringer's Solution contains sodium, chloride, potassium, calcium, and lactate, more closely resembling plasma's electrolyte profile.

Why Is It Used?

  • Rapid rehydration: Restores intravascular volume quickly, correcting dehydration, electrolyte imbalances, or supporting nutrient delivery.
  • Clinical evidence: Saline and balanced electrolyte solutions are frontline for dehydration, perioperative support, and acute illness, outperforming oral fluids for speed and reliability in moderate to severe cases.
    • [1]
  • Electrolyte balance: Lactated Ringer's minimizes risk of hyperchloremic acidosis seen with large saline infusions .

References:

[1] Sterns RH, et al. "Fluid and Electrolyte Therapy in Adults." N Engl J Med. 2019;381:1770-1781. Link
[2] Hoorn EJ, et al. "Hyponatremia and Fluid Therapy." N Engl J Med. 2021;384:2025-2036. Link
[3] Raghunathan K, et al. "Choice of fluid in acute illness: what should be given?" Curr Opin Crit Care. 2015;21(4):309-315. Link

Vitamin C (Ascorbic Acid)

What Is It?

A water-soluble antioxidant, essential for collagen synthesis, immune support, and cellular protection from oxidative stress.

Why Is It Used?

  • Immunity: High-dose vitamin C reduces duration/severity of upper respiratory infections and may improve outcomes in sepsis/critical illness .
  • Antioxidant action: Protects endothelial function, reduces oxidative damage .
  • IV advantage: IV ascorbic acid achieves plasma concentrations 70–100x higher than oral dosing, crucial for acute antioxidant needs .

References:

[4]Hemilä H, Chalker E. "Vitamin C for preventing and treating the common cold." Cochrane Database Syst Rev. 2013. Link
[5]Fowler AA, et al. "Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure." JAMA. 2019;322(13):1261-1270. Link
[6]Carr AC, Maggini S. "Vitamin C and Immune Function." Nutrients. 2017;9(11):1211. Link
[7]Padayatty SJ, et al. "Vitamin C pharmacokinetics: implications for oral and intravenous use." Ann Intern Med. 2004;140(7):533-537. Link

B-Complex Vitamins

What Is It?

A group of eight essential water-soluble vitamins (B1, B2, B3, B5, B6, B7, B9, B12) required for metabolic, neurological, and cellular functions.

Why Are They Used?

  • Energy production: Serve as coenzymes in ATP generation and metabolism .
  • Neurological health: Deficiencies can cause neuropathy, fatigue, cognitive changes .
  • IV use: Ensures direct, full absorption for individuals with GI disorders or increased needs .

References:

[8] Kennedy DO. "B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review." Nutrients. 2016;8(2):68. Link
[9] Stover PJ. "Vitamin B12 and older adults." Curr Opin Clin Nutr Metab Care. 2010;13(1):24-27. Link
[10] Hellmann H, Mooney S. "Vitamin B6: A Molecule for Human Health?" Molecules. 2010;15(1):442-459. Link

Vitamin B12 (Methylcobalamin or Hydroxocobalamin)

What Is It?

A key water-soluble vitamin necessary for DNA synthesis, red blood cell production, and nervous system maintenance.

Why Is It Used?

  • Deficiency support: Corrects anemia, neuropathy, and cognitive symptoms .
  • Cognitive and energy boost: Supplementation may improve energy, mental clarity, and mood, especially in deficiency states .
  • IV benefit: Effective even in cases of impaired GI absorption (e.g., post-gastric surgery) .

References:

[11] O'Leary F, Samman S. "Vitamin B12 in health and disease." Nutrients. 2010;2(3):299-316. Link
[12] Smith AD, et al. "Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial." PLoS One. 2010;5(9):e12244. Link
[13] Sanz-Cuesta BE, et al. "Vitamin B12 deficiency: recognition and management." Am Fam Physician. 2021;104(2):168-175. Link

Magnesium

What Is It?

A critical mineral involved in more than 300 enzymatic reactions—regulating muscle/nerve function, blood glucose, and blood pressure.

Why Is It Used?

  • Migraine relief: IV magnesium can abort acute migraine attacks .
  • Muscle relaxation: Eases cramps and muscle tension, helps with restless legs and sleep .
  • Metabolic/cardiovascular benefits: Maintains healthy heart rhythm, supports energy and bone health ....

References:

[14] Sun-Edelstein C, Mauskop A. "Role of magnesium in the pathogenesis and treatment of migraines." Clin J Pain. 2009;25(5):446-452. Link
[15] Gröber U, Schmidt J, Kisters K. "Magnesium in prevention and therapy." Nutrients. 2015;7(9):8199-8226. Link
[16] DiNicolantonio JJ, O'Keefe JH, Wilson W. "Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis." Open Heart. 2018;5(1):e000668. Link

Glutathione

What Is It?

A tripeptide antioxidant (glutamate, cysteine, glycine) that protects cells from oxidative damage and supports detoxification.

Why Is It Used?

  • Detoxification: Major hepatic antioxidant; supports phase II liver detoxification .
  • Neuroprotection: Depletion associated with neurodegenerative diseases .
  • IV use: Rapidly raises blood glutathione in cases of oxidative stress, though more clinical research is needed for routine use .

References:

[17] Lu SC. "Regulation of glutathione synthesis." Mol Aspects Med. 2009;30(1-2):42-59. Link
[18] Zeevalk GD, et al. "Glutathione and Parkinson's disease: is this the elephant in the room?" Biomed Pharmacother. 2008;62(4):236-249. Link
[19] Allen J, Bradley RD. "Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers." J Altern Complement Med. 2011;17(9):827-833. Link

Zinc

What Is It?

A trace element essential for immune cell function, wound healing, and antioxidant defense.

Why Is It Used?

  • Immunity: Supplementation shown to reduce incidence and duration of infections .
  • Wound healing: Critical for DNA synthesis and cell division, especially in skin .
  • IV use: Occasionally utilized in clinical nutrition or acute deficiency states .

References:

[20] Prasad AS. "Zinc in human health: effect of zinc on immune cells." Mol Med. 2008;14(5-6):353-357. Link
[21] Lansdown ABG, Sampson B, Rowe A. "Sequential changes in trace metals, metallothionein and calprotectin in skin wounds of zinc- and calcium-supplemented rats." Wound Repair Regen. 2000;8(1):60-72. Link
[22] Wessels I, Maywald M, Rink L. "Zinc as a gatekeeper of immune function." Nutrients. 2017;9(12):1286. Link

Biotin (Vitamin B7)

What Is It?

A B-vitamin essential for fatty acid synthesis and keratin production.

Why Is It Used?

  • Hair/skin/nails: Supplementation supports keratin structure and may benefit brittle nails or hair thinning .
  • Metabolic support: Coenzyme for carboxylase enzymes in gluconeogenesis and energy metabolism .

References:

[23] Patel DP, et al. "A Review of the Use of Biotin for Hair Loss." Skin Appendage Disord. 2017;3(3):166-169. Link
[24] Zempleni J, et al. "Biotin." Adv Nutr. 2018;9(5):497-498. Link

Amino Acids & Taurine

What Are They?

Amino acids are building blocks of proteins; Taurine is a sulfur-containing amino acid important in cardiovascular and neurological function.

Why Are They Used?

  • Muscle recovery: Amino acids, especially branched-chain, support muscle repair after exercise or illness .
  • Hydration/energy: IV amino acid solutions are standard in clinical nutrition (e.g., TPN) for catabolic patients .
  • Taurine: Regulates calcium signaling, supports cardiac contractility and neurological health .

References:

[25] Wolfe RR. "Branched-chain amino acids and muscle protein synthesis in humans: myth or reality?" J Int Soc Sports Nutr. 2017;14:30. Link
[26] Ballmer PE, McNurlan MA. "Amino Acid Requirements in Clinical Nutrition." Nutr Clin Pract. 2019;34(4):494-506. Link
[27] Ripps H, Shen W. "Review: taurine: a 'very essential' amino acid." Mol Vis. 2012;18:2673-2686. Link

MIC (Methionine, Inositol, Choline) Blend

What Is It?

A "lipotropic" injection used in some IV protocols to support fat metabolism and liver health.

Why Is It Used?

  • Methionine: Essential amino acid, supports methylation and liver detox .
  • Inositol/Choline: Involved in lipid transport, cell membrane function, and potentially liver fat reduction .

References:

[28] Zeisel SH. "Choline: Critical Role During Fetal Development and Dietary Requirements in Adults." Annu Rev Nutr. 2006;26:229-250. Link
[29] Vance DE. "Physiological roles of phosphatidylethanolamine N-methyltransferase." Biochim Biophys Acta. 2013;1831(3):626-632. Link

Notes on IV Therapy Evidence & Safety

  • Most ingredients have robust safety records when used as clinically indicated; IV administration always carries small risks (phlebitis, allergy, infection).
  • While some protocols (e.g., for dehydration, deficiency correction) are well-established, many "wellness" uses are extrapolated from medical literature and not FDA-approved for health optimization in otherwise healthy adults.
  • All infusions at IVÉ Wellness are compounded in licensed sterile pharmacies and administered under appropriate medical supervision.